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(for example, eight nucleotides). By contrast, proteins require repeat motifs comprising 35 amino acids (105 base pairs of genomic sequence) to recognize a single RNA base with specificity. Therefore, to recognize eight nucleotides, 280 amino acids (840 base pairs of genomic sequence) would be required. Compared to the eight base pairs required for an RNA, protein based nucleic acid recognition requires substantially more genomic sequence17. b RNA can fold into complex three dimensional structures that can specifically bind various ligands, including small molecules and peptides18. c RNA is suitable for transient expression, because a fully functional RNA can be generated immediately following transcription and processing but can also be rapidly degraded. Together, this allows RNA effectors to be produced in quick pulses. Proteins, however, NFL Wholesale Jerseys
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heritable. For instance, processed pseudogenes were once RNA transcripts that have been genomically integrated. In addition, telomerase uses an RNA template to add telomeric repeats to the ends of chromosomes. ORF, open reading frame; Pol II, RNA polymerase II.